Females had a higher arsenic methylation capacity compared to males.Younger subjects had lower primary arsenic methylation capacity.Mean urinary concentrations of dimethylarsonic acid (DMA), monomethylarsonic acid (MMA), inorganic arsenic (i As), and total arsenic (TAs) were 200.50, 46.71, 52.96, and 300.17 μg/L, respectively.
Methylated arsenicals that contain trivalent arsenic (As.
Pretreatment with methionine failed to exert any significant acceleratory effect on the methylation of arsenic trioxide.
The decreasing pattern of the SAM level in the liver following administration of arsenic trioxide and the DMA behavior in the liver and urine following administration of SAM and arsenic trioxide revealed that SAM accelerated the methylation of inorganic arsenic.
Thus, production of methylated trivalent arsenicals in the course of i As metabolism may result in GR inhibition, shifting the GSH: GSSG ratio and the cellular redox balance.
Changes in the cellular redox status have been linked to modulations of gene transcription that underlie an uncontrolled cell proliferation, the main attribute of cancerous growth.